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The study was conducted at Department of Psychiatry the University Parma (Italy) [see Clinical Studies (14.2)]. A 2-year, randomized, double-blind, placebo-controlled trial investigated the effects of sibutramine (20 mg/d for 14 days) on body weight, composition, and insulin resistance (measurement of diabetes) for 8 weeks. Sibutramine was compared to placebo by means Metformin ohne rezept rezeptfrei of a double-blind crossover study. The primary end points were changes in body weight, composition, and total cholesterol triglycerides [n, p., and p− values, 0.10 for all; data from all measurements were standardized to 1].
Statistical analyses were performed using analysis of variance and a nonparametric Kruskal-Wallis test. Baseline values are given as means ±SD.
RESULTS:
Body weight decreased significantly in the sibutramine group compared with baseline (p < 0.05). Body weight was significantly below baseline in sibutramine subjects with total cholesterol and triglycerides levels ≤ 400 mg/dL, which indicates that sibutramine was effective only in subjects with levels ≥ 400 mg/dL. Fasting and postprandial triglycerides decreased significantly, but they did not reach statistical significance [p > 0.05 for both]. Insulin-resistant areas fasting plasma glucose and insulin concentrations did not change significantly, however.
CONCLUSIONS:
Sibutramine, a specific inhibitor of serotonin reuptake, is capable increasing body weight in subjects with relatively low levels of fasting and postprandial plasma glucose insulin concentrations.
TRIAL REGISTRATION:
ClinicalTrials.gov NCT01497513. As for the third, he added, "I guess you just need to keep getting better. You just gotta canada pharmacy express keep working very hard and your eyes open." There's a lot of good stuff going on in the world of gaming and it comes in all forms. This week on Pocket Gamer we're the edge of our seats as you play a game like you've never played it before, take an interview with the creators at top of UK indie scene, and even help out a little in the process with a new edition of Pocket Gamer's 'Newswire'.
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